Isoquinolone Synthesis through SNAr Reaction of 2-Halobenzonitriles with Ketones Followed by Cyclization
Muhammad Shareef Mayo, Xiaoqiang Yu*, Xiujuan Feng, Yoshinori Yamamoto and Ming Bao*
*State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China, Email: yuxiaoqiangdlut.edu.cn, mingbaodlut.edu.cn
M. S. Mayo, X. Yu, X. Feng, Y. Yamamoto, M. Bao, J. Org. Chem., 2015, 80, 3998-4002.
DOI: 10.1021/acs.joc.5b00357
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Abstract
KOtBu-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Cu(OAc)2-catalyzed cyclization gives isoquinolone derivatives in good yields.
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Key Words
ID: J42-Y2015