Fe-Catalyzed Direct α C-H Amination of Carbonyl Compounds
Siva Murru*, Charles Seth Lott, Frank R. Fronczek and Radhey S. Srivastava*
*Department of Chemistry, University of Louisiana at
Lafayette, Lafayette, Louisiana 70504, United States, Email: rss1805
louisiana.edu,
sxm2239louisiana.edu
S. Murru, C. S. Lott, F. R. Fronczek, R. S. Srivastava, Org. Lett., 2015, 17, 2122-2125.
DOI: 10.1021/acs.orglett.5b00710
Abstract
The use of arylhydroxylamines as aminating agents enables a direct Fe-catalyzed α-amination of 1,3-dicarbonyl compounds. This operationally simple procedure, that works at low temperatures in short reaction times and produces high yields with excellent N-selectivity, allows convenient access to α-amino carbonyl derivatives.
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Key Words
ID: J54-Y2015
