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Copper-Catalyzed Radical Methylation/C-H Amination/Oxidation Cascade for the Synthesis of Quinazolinones

Yajie Bao, Yizhe Yan, Kun Xu, Jihu Su, Zhenggen Zha and Zhiyong Wang*

*Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Email: zwang3ustc.edu.cn

Y. Bao, Y. Yan, K. Xu, J. Su, Z. Zha, Z. Wang, J. Org. Chem., 2015, 80, 4736-4742.

DOI: 10.1021/acs.joc.5b00191 (free Supporting Information)


 

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Abstract

A copper-catalyzed radical methylation/sp3 C-H amination/oxidation reaction provides quinazolinone via a cascade reaction, in which dicumyl peroxide acts not only as an oxidant but also as an efficient methyl source.

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Key Words

Quinazolinones, Peroxides


ID: J42-Y2015