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Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols

Xiang Sun, Xinyao Li, Song Song, Yuchao Zhu, Yu-Feng Liang and Ning Jiao*

*State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd. 38, Beijing 100191, China, Email: jiaoningbjmu.edu.cn

X. Sun, X. Li, S. Song, Y. Zhu, Y.-F. Liang, N. Jiao, J. Am. Chem. Soc., 2015, 137, 6059-6066.

DOI: 10.1021/jacs.5b02347 (free Supporting Information)



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Abstract

In an efficient Mn-catalyzed aerobic oxidative hydroxyazidation of olefins for synthesis of β-azido alcohols, an aerobic oxidative generation of azido radical is a key process. The reaction offers broad substrate scope, the use of an inexpensive Mn-catalyst, high efficiency, easy operation under air, and mild conditions at room temperature.

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Key Words

1,2-azido alcohols, oxygen


ID: J48-Y2015