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Chromium(II)-Catalyzed Amination of N-Heterocyclic Chlorides with Magnesium Amides

Andreas K. Steib, Sarah Fernandez, Olesya M. Kuzmina, Martin Corpet, Corinne Gosmini, Paul Knochel*

*Department of Chemistry, Ludwig-Maximilians-Universitšt, Butenandtstr. 5-13, 81377 Munich, Germany, Email: paul.knochelcup.uni-muenchen.de

A. K. Steib, S. Fernandez, O. M. Kuzmina, M. Corpet, C. Gosmini, P. Knochel, Synlett, 2015, 26, 1049-1054.

DOI: 10.1055/s-0034-1380178 (free Supporting Information)


Abstract

In a ligand-free chromium(II)-catalyzed amination reaction of various N-heterocyclic chlorides, CrCl2 regioselectively catalyzes the reaction of chloropyridines, chloroquinolines, chloroisoquinolines, and chloroquinoxalines with a broad range of magnesium amides in the presence of lithium chloride as additive. The reactionse provide the desired aminated products in good yield.

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Key Words

chromium, amination, magnesium amides, heterocycles, pyridines, quinolines


ID: J60-Y2015