An Efficient, Mild, Solvent-Free, One-Pot Three-Component Mannich Reaction Catalyzed by (C4H12N2)2[BiCl6]Cl·H2O
Hongfei Lu*, Runze Wu, Helong Cheng, Shipeng Nie, Yan Tang, Yuhua Gao, Zhibin Luo*
*Jiangsu University of Science and Technology; Jiangsu
University, Zhenjiang 212003, P. R. of China, Email: zjluhf1979
hotmail.com,
zhibinluohotmail.com
H. Lu, R. Wu, H. Cheng, S. Nie, Y. Tang, Y. Gao, Z. Luo, Synthesis, 2015, 47, 1280-1290.
DOI: 10.1055/s-0034-1380278
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Abstract
An efficient and practical one-pot Mannich reaction of aromatic ketones with aldehydes and amines at room temperature under solvent-free conditions is catalyzed by (C4H12N2)2[BiCl6]Cl·H2O. The catalyst can be recycled multiple times by simple isolation protocols without compromising the catalytic efficiency.
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Key Words
Mannich Reaction, Multicomponent Reactions, Lewis acids, Mannich bases, amines, catalysis, aldehydes
ID: J66-Y2015
