Synthesis of 1,2,3-Substituted Pyrroles from Propargylamines via a One-Pot Tandem Enyne Cross Metathesis-Cyclization Reaction
Helene Chachignon, Nicoḷ Scalacci, Elena Petricci and Daniele Castagnolo*
*Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, SE1 9NH, Email: daniele.castagnolokcl.ac.uk
H. Chachignon, N. Scalacci, E. Petricci, D. Castagnolo, J. Org. Chem., 2015, 80, 5287-5295.
DOI: 10.1021/acs.joc.5b00222
see article for more reactions
Abstract
Enyne cross metathesis of propargylamines with ethyl vinyl ether provides a series of substituted pyrroles, bearing alkyl, aryl, and heteroaryl substituents under microwave irradiation.
see article for more examples
proposed diene intermediate
Key Words
enyne metathesis, pyrroles, microwave synthesis
ID: J42-Y2015