N-Methylation of Amines with Methanol at Room Temperature
Vasily N. Tsarev, Yuna Morioka, Joaquim Caner, Qing Wang, Richiro Ushimaru, Akihiko Kudo, Hiroshi Naka and Susumu Saito*
*Research Center for Materials Science and Graduate School of
Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Email: saito.susumu
f.mbox.nagoya-u.ac.jp
V. N. Tsarev, Y. Morioka, J. Caner, Q. Wang, R. Ushimaru, A. Kudo, H. Naka, S. Saito, Org. Lett., 2015, 17, 2530-2533.
DOI: 10.1021/acs.orglett.5b01063
Abstract
A silver-loaded titanium dioxide (Ag/TiO2) photocatalyst enables a facile N-methylation of amines with methanol at room temperature under UV-vis light irradiation. This method tolerates various functional groups including N-benzyl, N-allyl, N-Boc, hydroxyl, ether, acetal, carboxamide, formamide, and olefin groups.
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Key Words
ID: J54-Y2015
