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A Direct Metal-Free Decarboxylative Sulfono Functionalization (DSF) of Cinnamic Acids to α,β-Unsaturated Phenyl Sulfones

Rahul Singh, Bharat Kumar Allam, Neetu Singh, Kumkum Kumari, Satish Kumar Singh and Krishna Nand Singh*

*Department of Chemistry (Centre of Advanced Study), Banaras Hindu University, Varanasi 221005, India, Email: knsinghbhu.ac.in

R. Singh, B. K. Allam, N. Singh, K. Kumari, S. K. Singh, K. N. Singh, Org. Lett., 2015, 17, 2656-2659.

DOI: 10.1021/acs.orglett.5b01037 (free Supporting Information)



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Abstract

A metal-free room temperature decarboxylative cross-coupling between cinnamic acids and arylsulfonyl hydrazides provides (E)-vinyl sulfones. A regio- and stereoselective synthesis of 22 derivatives with diverse structural features has been achieved.

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Key Words

vinyl sulfones, TBHP, iodine


ID: J54-Y2015