Selective Copper-Catalyzed N-Arylation of Lactams with Arylboronic Acids under Base- and Ligand-Free Conditions
Thulasiram Bathini, Vikas Singh Rawat, Bojja Sreedhar*
*Inorganic & Physical Chemistry Division, Indian Institute of
Chemical Technology (Council of Scientific & Industrial Research), Hyderabad -
500007, India, Email: sreedharb
iict.res.in
T. Bathini, V. S. Rawat, B. Sreedhar, Synlett, 2015, 26, 1348-1351.
DOI: 10.1055/s-0034-1380741
Abstract
An oxidative copper-catalyzed arylation of various ring-size lactams with arylboronic acids gives N-arylated products in good yield without any additional bases, ligands, or additives.
see article for more examples
Key Words
lactams, γ-lactams, ε-lactams, catalysis, copper, cross-coupling, oxidation, TBHP
ID: J60-Y2015
