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Synthesis of Isatins through Direct Oxidation of Indoles with IBX-SO3K/NaI

Angla Bredenkamp, Fabian Mohr, Stefan F. Kirsch*

*Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany, Email: sfkirschuni-wuppertal.de

A. Bredenkamp, F. Mohr, S. F. Kirsch, Synthesis, 2015, 47, 1937-1943.

DOI: 10.1055/s-0034-1380517 (free Supporting Information)


Abstract

The reagent mixture NaI/IBX-SO3K, containing a sulfonylated derivative of 2-iodoxybenzoic acid, was employed for an oxidative direct conversion of indoles into isatins. A synthetic route toward IBX-SO3K and the X-ray crystal structure of the reagent are presented.

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Key Words

IBX, oxidation, indoles, isatins, heterocycles


ID: J66-Y2015