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Synergistic Gold and Iron Dual Catalysis: Preferred Radical Addition toward Vinyl-Gold Intermediate over Alkene

Haihui Peng, Novruz G. Akhmedov, Yu-Feng Liang, Ning Jiao* and Xiaodong Shi*

*Peking University, Xue Yuan Road 38, Beijing 100191, China; West Virginia University, Morgantown, West Virginia 26506, United States, Email: Jiaoningbjmu.edu.cn, Xiaodong.Shimail.wvu.edu

H. Peng, N. G. Akhmedov, Y.-F. Liang, N. Jiao, X. Shi, J. Am. Chem. Soc., 2015, 137, 8912-8915.

DOI: 10.1021/jacs.5b05415 (free Supporting Information)


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Abstract

A dual catalytic approach offers readily access to substituted heterocycle aldehydes via oxygen radical addition to vinyl-gold intermediates under Fe catalyst assistance. This system offers good functional group compatibility for the synthesis of substituted oxazole, indole, and benzofuran aldehydes.

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Key Words

Oxazoles, Oxygen


ID: J48-Y2015