A Concise and Atom-Economical Suzuki-Miyaura Coupling Reaction Using Unactivated Trialkyl- and Triarylboranes with Aryl Halides
Hongmei Li*, Yong-Li Zhong*, Cheng-yi Chen, Ashley E. Ferraro and Dengjin Wang
*Process Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States, Email: hongmei06gmail.com, yongli_zhongmerck.com
H. Li, Y.-L. Zhong, C.-y. Chen, A. E. Ferraro, D. Wang, Org. Lett., 2015, 17, 3616-3619.
DOI: 10.1021/acs.orglett.5b01720 (free Supporting Information)
see article for more reactions
A concise and atom-economical Suzuki-Miyaura coupling of trialkyl- and triarylboranes with aryl halides is a general and practical method that efficiently utilizes peralkyl and peraryl groups of the unactivated trialkyl- and triarylboranes. The trialkylboranes could be generated in situ from hydroboration of terminal alkenes.
see article for more examples