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PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent

Matthew K. Nielsen, Christian R. Ugaz, Wenping Li and Abigail G. Doyle*

*Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Email: agdoyleprinceton.edu

M. K. Nielsen, C. R. Ugaz, W. Li, A. G. Doyle, J. Am. Chem. Soc., 2015, 137, 9571-9574.

DOI: 10.1021/jacs.5b06307


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Abstract

PyFluor is an inexpensive and thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols with only minor formation of elimination side products. The reagents combines selectivity, safety, and economic viability.


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Key Words

alkyl fluorides, benzyl fluorides


ID: J48-Y2015