Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins
Fernando Fernández-Nieto, Josep Mas Roselló, Simone Lenoir, Simon Hardy and Jonathan Clayden*
*School of Chemistry, University of Manchester, Oxford Road,
Manchester M13 9PL, U.K., Email: clayden
manchester.ac.uk
F. Fernández-Nieto, J. M. Roselló, S. Lenoir, S. Hardy, J. Clayden, Org. Lett., 2015, 17, 3838-3841.
DOI: 10.1021/acs.orglett.5b01803
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Abstract
Palladium(II) trifluoroacetate catalyzes the C-arylation of N,N-disubstituted hydantoins by aryl iodides in good yield. The reaction is successful with various hydantoins and a range of electron-rich and electron-poor aryl iodides.
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Key Words
ID: J54-Y2015
