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C-Alkynylation of Cyclopropanols

R. V. N. S. Murali, Nagavaram Narsimha Rao and Jin Kun Cha*

*Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States, Email:

R. V. N. S. Murali, N. N. Rao, J. K. Cha, Org. Lett., 2015, 17, 3854-3856.

DOI: 10.1021/acs.orglett.5b01789 (free Supporting Information)

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An alkynylation of cyclopropanols with 1-bromo-1-alkynes provides synthetically useful alk-4-yn-1-ones. In this C-C bond formation, functionalized cyclopropanols act as a new class of homoenolate equivalent.

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Key Words

alkynylation, carbonyl compounds

ID: J54-Y2015