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A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

Yuelu Zhu, Cheng Li, Jidong Zhang, Mengyao She, Wei Sun, Kerou Wan, Yaqi Wang, Bin Yin, Ping Liu and Jianli Li*

*Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education and College of Chemistry & Materials Science, Northwest University, Xi’an Shaanxi 710127, P. R. China, Email: lijianlinwu.edu.cn

Y. Zhu, C. Li, J. Zhang, M. She, W. Sun, K. Wan, Y. Wang, B. Yin, P. Liu, J. Li, Org. Lett., 2015, 17, 3872-3875.

DOI: 10.1021/acs.orglett.5b01854 (free Supporting Information)


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Abstract

A convenient and efficient FeCl3/I2-catalyzed aerobic oxidative coupling of amidines and chalcones provides tetrasubstituted imidazoles in high regioselectivity and yields. The reaction offers good functional group tolerance, and mild reaction conditions.

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Key Words

imidazoles, oxygen


ID: J54-Y2015