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Scope and Mechanistic Analysis for Chemoselective Hydrogenolysis of Carbonyl Compounds Catalyzed by a Cationic Ruthenium Hydride Complex with a Tunable Phenol Ligand

Nishantha Kalutharage and Chae S. Yi*

*Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201-1881, United States, Email: chae.yimarquette.edu

N. Kalutharage, C. S. Yi, J. Am. Chem. Soc., 2015, 137, 11105-11114.

DOI: 10.1021/jacs.5b06097 (free Supporting Information)


Abstract

In the presence of a phenol ligand, a cationic ruthenium hydride complex exhibited high catalytic activity for the hydrogenolysis of carbonyl compounds to yield the corresponding aliphatic products. The reaction showed exceptionally high chemoselectivity toward the carbonyl reduction over alkene hydrogenation.

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Key Words

deoxygenation, hydrogen, 2-PrOH


ID: J48-Y2015