Synthesis of 1,2,4-Triazoles via Oxidative Heterocyclization: Selective C-N Bond Over C-S Bond Formation
Anupal Gogoi, Srimanta Guin, Suresh Rajamanickam, Saroj Kumar Rout and Bhisma K. Patel*
*Department of Chemistry, Indian Institute of Technology
Guwahati, Guwahati 781039, India, Email: patel
iitg.ernet.in
A. Gogoi, S. Guin, S. Rajamanickam, S. K. Rout, B. K. Patel, J. Org. Chem., 2015, 80, 9016-9027.
DOI: 10.1021/acs.joc.5b00956
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Abstract
Cu(II) catalyzes the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides. Upon prolonging the reaction time, the in situ generated thiones are transformed to 4,5-disubstituted 1,2,4-triazoles via a desulfurization process.
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Key Words
ID: J42-Y2015
