Copper-Catalyzed sp³ C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Kanako Nozawa-Kumada, Jun Kadokawa, Takehiro Kameyama and Yoshinori Kondo*

*Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan, Email: ykondom.tohoku.ac.jp

K. Nozawa-Kumada, J. Kadokawa, T. Kameyama, Y. Kondo, Org. Lett., 2015, 17, 4479-4481.

DOI: 10.1021/acs.orglett.5b02235

Abstract

A copper-catalyzed sp³ C-H functionalization of 2-alkyl-N-substituted benzamides provides an efficient approach to various functionalized isoindolinones without preparation of halogenated substitutes, use of expensive transition metals, or toxic Sn or CO gas.

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Key Words

isoindolinones, di-tert-butyl-peroxide

ID: J54-Y2015

Copper-Catalyzed sp3 C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Kanako Nozawa-Kumada, Jun Kadokawa, Takehiro Kameyama and Yoshinori Kondo*

Copper-Catalyzed sp³ C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones