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A Sustainable Multicomponent Pyrimidine Synthesis

Nicklas Deibl, Kevin Ament and Rhett Kempe*

*Anorganische Chemie II−Katalysatordesign, Universität Bayreuth, 95440 Bayreuth, Germany, Email: kempeuni-bayreuth.de

N. Deibl, K. Ament, R. Kempe, J. Am. Chem. Soc., 2015, 137, 12804-12807.

DOI: 10.1021/jacs.5b09510


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Abstract

A regioselective, iridium-catalyzed multicomponent synthesis of pyrimidines from amidines and up to three (different) alcohols proceeds via a sequence of condensation and dehydrogenation steps. While the condensation steps deoxygenate the alcohol components, the dehydrogenations lead to aromatization. PN5P-Ir-pincer complexes catalyze this sustainable multicomponent process most efficiently.

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Key Words

pyrimidines, multicomponent reactions


ID: J48-Y2015