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Copper N-Heterocyclic Carbene Complexes As Active Catalysts for the Synthesis of 2-Substituted Oxazolines from Nitriles and Aminoalcohols

Michael Trose, Fa´ma Lazreg, Mathieu Lesieur and Catherine S. J. Cazin*

*EaStCHEM School of Chemistry, University of St. Andrews, St. Andrews, KY16 9ST, U.K., Email: cc111st-andrews.ac.uk

M. Trose, F. Lazreg, M. Lesieur, C. S. J. Cazin, J. Org. Chem., 2015, 80, 9910-9914.

DOI: 10.1021/acs.joc.5b01382 (free Supporting Information)


 

Abstract

Using copper-NHC complexes, the reaction of nitriles with aminoalcohols provided 2-substituted oxazolines under milder and less wasteful conditions than those of previously reported methods.

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Key Words

2-oxazolines, green chemistry


ID: J42-Y2015