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Desulfonylative Methenylation of β-Keto Sulfones

Ganesh Pandey* and Janakiram Vaitla

*Molecular Synthesis and Drug Discovery Laboratory, Centre of Biomedical Research, SGPGIMS Campus Lucknow 226014, India, Email: gp.pandeycbmr.res.in

G. Pandey, J. Vaitla, Org. Lett., 2015, 17, 4890-4893.

DOI: 10.1021/acs.orglett.5b02455 (free Supporting Information)


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Abstract

Regioselective C-C bond fragmentation of cyclopropanes followed by desulfonylation enables a one-step strategy for the synthesis of α-methenyl ketones from β-keto sufones. Success of the methodology is elaborated for the synthesis of chromanones and isoflavanones in one-step.

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Key Words

enones, terminal alkenes


ID: J54-Y2015