Ligand- and Acid-Free Gold(I) Chloride Catalyzed Hydration of Terminal Alkynes
Atanu Kumar Das, Sangseung Park, Senthilkumar Muthaiah, Soon Hyeok Hong*
*Department of Chemistry, College of Natural Sciences, Seoul
National University, Seoul 151-747, Republic of Korea, Email: soonhong
snu.ac.kr
A. K. Das, S. Park, S. Muthaiah, S. H. Hong, Synlett, 2015, 26, 2517-2520.
DOI: 10.1055/s-0035-1560573
see article for more reactions
Abstract
Aliphatic and aromatic terminal alkynes can be hydrated by the AuCl/MeOH catalyst system to afford the corresponding methyl ketones in good yields without any additive, ligand, or acid promoter. This methodology is simple, mild, and convenient.
see article for more examples
Key Words
hydration, alkynes, ketones, gold, homogeneous catalysis
ID: J60-Y2015
