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Photoinduced, Copper-Catalyzed Carbon-Carbon Bond Formation with Alkyl Electrophiles: Cyanation of Unactivated Secondary Alkyl Chlorides at Room Temperature

Tanvi S. Ratani, Shoshana Bachman, Gregory C. Fu* and Jonas C. Peters*

*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States, Email: gcfucaltech.edu, jpeterscaltech.edu

T. S. Ratani, S. Bachman, G. C. Fu, J. C. Peters, J. Am. Chem. Soc., 2015, 137, 13902-13907.

DOI: 10.1021/jacs.5b08452 (free Supporting Information)


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Abstract

In the presence of inexpensive CuI and a readily available light source (UVC compact fluorescent light bulb), a wide array of secondary alkyl halides undergo cyanation in good yield.

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Key Words

cyanation


ID: J48-Y2015