Visible-Light-Driven Photocatalytic Initiation of Radical Thiol-Ene Reactions Using Bismuth Oxide

Olugbeminiyi O. Fadeyi*, James J. Mousseau, Yiqing Feng, Christophe Allais, Philippe Nuhant, Ming Z. Chen, Betsy Pierce and Ralph Robinson

*Worldwide Medicinal Chemistry, Pfizer, 445 Eastern Point Road, Groton, Connecticut 06340, United States, Email: Olugbeminiyi.fadeyipfizer.com

O. O. Fadeyi, J. J. Mousseau, Y. Feng, C. Allais, P. Nuhant, M. Z. Chen, B. Pierce, R. Robinson, Org. Lett., 2015, 17, 5756-5759.

DOI: 10.1021/acs.orglett.5b03184

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Abstract

Low catalyst loading of Bi₂O₃ enables a nontoxic and inexpensive photocatalytic initiation of a mild and selective anti-Markovnikov hydrothiolation of olefins using visible light.

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Key Words

sulfides

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ID: J54-Y2015