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Gold Catalyzed Synthesis of Substituted Furan by Intermolecular Cascade Reaction of Propargyl Alcohol and Alkyne

Seyedmorteza Hosseyni, Yijin Su and Xiaodong Shi*

*Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States, Email: xmshiusf.edu

S. Hosseyni, Y. Su, X. Shi, Org. Lett., 2015, 17, 6010-6013.

DOI: 10.1021/acs.orglett.5b02980 (free Supporting Information)


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Abstract

The combination of triazole-gold (TA-Au) and copper catalysts enabled a synthesis of substituted furans in an one-pot three-step reaction cascade. The reaction tolerates a large substrate scope with simple starting materials and provides di-, tri-, and tetrasubstituted furans in good to excellent yields.

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Key Words

furans


ID: J54-Y2015