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Metal-Free Microwave-Assisted Decarboxylative Elimination for the Synthesis of Olefins

Shu-Wei Wu, Jia-Li Liu and Feng Liu*

*Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People’s Republic of China, Email: fliu2suda.edu.cn

S.-W. Wu, J.-L. Liu, F. Liu, Org. Lett., 2016, 18, 1-3.

DOI: 10.1021/acs.orglett.5b03069 (free Supporting Information)


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Abstract

A microwave-assisted, metal-free direct decarboxylative elimination of arylacetic acids in the presence of PIFA as oxidant readily provides alkenes in good yields.

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Key Words

Elimination, PIFA, Microwave Synthesis


ID: J54-Y2016