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Aqueous Compatible Protocol to Both Alkyl and Aryl Thioamide Synthesis

Jianpeng Wei, Yiming Li and Xuefeng Jiang*

*Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China, Email: xfjiangchem.ecnu.edu.cn

J. Wei, Y. Li, X. Jiang, Org. Lett., 2016, 18, 340-343.

DOI: 10.1021/acs.orglett.5b03541 (free Supporting Information)


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Abstract

In an efficient aqueous synthesis of thioamides from aldehydes and N-substituted formamides, sodium sulfide serves as the sulfur source in water, which makes this method very practical and efficient. Furthermore, late-stage modifications of bioactive molecules are demonstrated.

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Key Words

thioamides (thioacylation, thionation), multicomponent reactions


ID: J54-Y2016