Benzylic Phosphates in Friedel-Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes
Gangaram Pallikonda and Manab Chakravarty*
*Department of Chemistry, Birla Institute of Technology and
Sciences, Pilani Hyderabad Campus, Jawahar nagar, Shameerpet Mandal, Hyderabad,
Telangana 500078, India, Email: manabchakravarty
gmail.com
G. Pallikonda, M. Chakravarty, J. Org. Chem., 2016, 81, 2135-2142.
DOI: 10.1021/acs.joc.5b02441
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Abstract
Easily reachable electron-poor/rich primary and secondary benzylic phosphates are suitably substrates for Friedel-Crafts benzylation reactions with only 1.2 equiv activated/deactivated arenes without additional solvent to access structurally and electronically diverse triarylmethanes, diarylethanes, and diarylmethanes with excellent yields and selectivities at room temperature within short reaction times.
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Key Words
Friedel-Crafts Alkylation, benzylation
ID: J42-Y2016
