Benzylic Phosphates in Friedel-Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes
Gangaram Pallikonda and Manab Chakravarty*
*Department of Chemistry, Birla Institute of Technology and Sciences, Pilani Hyderabad Campus, Jawahar nagar, Shameerpet Mandal, Hyderabad, Telangana 500078, India, Email: manabchakravartygmail.com
G. Pallikonda, M. Chakravarty, J. Org. Chem., 2016, 81, 2135-2142.
DOI: 10.1021/acs.joc.5b02441 (free Supporting Information)
see article for more reactions
Easily reachable electron-poor/rich primary and secondary benzylic phosphates are suitably substrates for Friedel-Crafts benzylation reactions with only 1.2 equiv activated/deactivated arenes without additional solvent to access structurally and electronically diverse triarylmethanes, diarylethanes, and diarylmethanes with excellent yields and selectivities at room temperature within short reaction times.
see article for more examples