Hydrazine in the Ugi Tetrazole Reaction
Pravin Patil, Ji Zhang, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling*
*University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands, Email: a.s.s.domlingrug.nl
P. Patil, J. Zhang, K. Kurpiewska, J. Kalinowska-Tłuścik, A. Dömling, Synthesis, 2016, 48, 1122-1130.
DOI: 10.1055/s-0035-1561353
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Abstract
The use of N-Boc-protected hydrazine in the Ugi tetrazole reaction provides a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles in good yield.
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Key Words
hydrazines, isocyanides, tetrazoles, multicomponent reactions
ID: J66-Y2016