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An Efficient Biomimetic Aerobic Oxidation of Alcohols Catalyzed by Iron Combined with Amino Acids

Guofu Zhang, Shasha Li, Jie Lei, Guihua Zhang, Xiaoqiang Xie, Chengrong Ding*, Renhua Liu*

*Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014; East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China, Email: dingcrzjut.edu.cn, liurhecust.edu.cn

G. Zhang, S. Li, J. Lei, G. Zhang, X. Xie, C. Ding, R. Liu, Synlett, 2016, 27, 956-960.

DOI: 10.1055/s-0035-1561290 (free Supporting Information)


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Abstract

A combination of FeCl3, L-valine and TEMPO oxidizes a wide range of primary/secondary benzyl, allylic, and heterocyclic alcohols to aldehydes and ketones with good to excellent isolated yields in the presence of oxygen.

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Key Words

alcohols, aldehydes, amino acids, iron, ketones, oxidation, TEMPO, oxygen


ID: J60-Y2016