Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1-Disubstituted Hydrazines
Tao Wang, Xiao Di, Chao Wang*, Li Zhou and Jian Sun*
*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 China, Email: wangchaocib.ac.cn, sunjiancib.ac.cn
T. Wang, X. Di, C. Wang, L. Zhou, J. Sun, Org. Lett., 2016, 18, 1900-1903.
DOI: 10.1021/acs.orglett.6b00675 (free Supporting Information)
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Lewis base promoted direct reductive hydrazination enables a straightforward and facile synthesis of 1,1-disubstituted hydrazines with very good yields. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively, various ketones and aldehydes reacted with phenylhdrazines.
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