Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones
Shyh-Ming Yang*, Gee-Hong Kuo, Michael D. Gaul and William V. Murray
*Cardiovascular and Metabolism Research, Janssen Research and
Development, LLC, Welsh & McKean Roads, Spring House, Pennsylvania 19477, United
States, Email: shyhyang99
yahoo.com
S.-M. Yang, G.-H. Kuo, M. D. Gaul, W. V. Murray, J. Org. Chem., 2016, 81, 3464-3469.
DOI: 10.1021/acs.joc.6b00317
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Abstract
Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of phosphonium salt-activated, cyclic 1,3-diones provide β-substituted cyclic enones in good isolated yield and high generality with respect to both substrates and coupling partners.
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Key Words
cyclohexenones, Suzuki coupling
ID: J42-Y2016
