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A Photoinduced Cobalt-Catalyzed Synthesis of Pyrroles through in Situ-Generated Acylazirines

Stefan Pusch, Danuta Kowalczyk and Till Opatz*

*Institute of Organic Chemistry, Johannes Gutenberg University, Duesbergweg 10-14, 55128 Mainz, Germany, Email: opatzuni-mainz.de

S. Pusch, D. Kowalczyk, T. Opatz, J. Org. Chem., 2016, 81, 4170-4178.

DOI: 10.1021/acs.joc.6b00511 (free Supporting Information)


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Abstract

Tetrasubstituted pyrroles can be synthesized in a one-pot procedure from isoxazoles via photoinduced in situ formation of acylazirines combined with a subsequent cobalt(II)-catalyzed ring expansion with 1,3-diketones.

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Key Words

pyrroles


ID: J42-Y2016