Organic Chemistry Portal

Abstracts

Search:

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

Pei-Qiang Huang*, Qi-Wei Lang and Yan-Rong Wang

*Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, PR China, Email: pqhuangxmu.edu.cn

P.-Q. Huang, Q.-W. Lang, Y.-R. Wang, J. Org. Chem., 2016, 81, 4235-4243.

DOI: 10.1021/acs.joc.6b00572 (free Supporting Information)


see article for more reactions

Abstract

The combination of amide activation by Tf2O with B(C6F5)3-catalyzed hydrosilylation with TMDS enables a one-pot reduction of secondary amides to amines under mild conditions with broad applicability and excellent chemoselectivity for many sensitive functional groups.

see article for more examples



Key Words

reduction of amides, TMDS


ID: J42-Y2016