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Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines

Yuan Huang, Rui-Zhi Huang and Yu Zhao*

*Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543, Email: zhaoyunus.edu.sg

Y. Huang, R.-Z. Huang, Y. Zhao, J. Am. Chem. Soc., 2016, 138, 6571-6576.

DOI: 10.1021/jacs.6b02372 (free Supporting Information)



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Abstract

An effient cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines delivers a range of synthetically useful allylic alcohols and amines in high enantiopurity. This convenient method employs commercially available and easy to handle catalysts and reagents.

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Key Words

esters, allylic alcohols


ID: J48-Y2016