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First Report on the Synthesis of Isatins via Pyridinium Chlorochromate Catalyzed Intramolecular Cyclization Reactions

Qiming Yue, Yaoling Wang, Li Hai, Li Guo, Hongmei Yin*, Yong Wu*

*Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. of China, Email: yinhongmeiscu.edu.cn, wyongscu.edu.cn

Q. Yue, Y. Wang, L. Hai, L. Guo, H. Yin, Y. Wu, Synlett, 2016, 27, 1292-1296.

DOI: 10.1055/s-0035-1561372 (free Supporting Information)


Abstract

Isatins can be synthesized from α-formyl amides in good yields via one-pot intramolecular cyclization-oxidation reaction in the presence of pyridinium chlorochromate (PCC). The reaction proceeded smoothly under air, offers a broad substrate scope, and is operationally simple.

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Key Words

isatins, PCC, one-pot, intramolecular cyclization


ID: J60-Y2016