Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans
Yubing Huang, Xianwei Li, Yue Yu, Chuanle Zhu, Wanqing Wu* and Huanfeng Jiang*
*School of Chemistry and Chemical Engineering, South China
University of Technology, Guangzhou 510640, P. R. China, Email: cewuwq
scut.edu.cn,
jianghfscut.edu.cn
Y. Huang, X. Li, Y. Yu, C. Zhu, W. Wu, H. Jiang, J. Org. Chem., 2016, 81, 5014-5020.
DOI: 10.1021/acs.joc.6b00568
see article for more reactions
Abstract
N-tosylhydrazones underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in good yields. The method features an inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation.
see article for more examples
Key Words
ID: J42-Y2016
