Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room Temperature
Feng-Cheng Jia, Zhi-Wen Zhou, Cheng Xu, Yan-Dong Wu* and An-Xin Wu*
*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China, Email: chwuydmail.ccnu.edu.cn, chwuaxmail.ccnu.edu.cn
F.-C. Jia, Z.-W. Zhou, C. Xu, Y.-D. Wu, A.-X. Wu, Org. Lett., 2016, 18, 2942-2945.
DOI: 10.1021/acs.orglett.6b01291 (free Supporting Information)
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A synergetic tert-butyl hydroperoxide/K3PO4-promoted oxidative cyclization enables a facile synthesis of various functionalized quinazolin-4(3H)-ones from commercially available isatins and amidine hydrochlorides at room temperature.
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