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A Mild Strategy for the Preparation of Phenols via the Ligand-Free Copper-Catalyzed O-Arylation of para-Toluenesulfonic Acid

Bryan Yong-Hao Tan, Yong-Chua Teo*

*Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Nanyang Walk, Singapore 637616, Singapore, Email: yongchua.teonie.edu.sg

B. Y.-H. Tan, Y.-C. Teo, Synlett, 2016, 27, 1814-1819.

DOI: 10.1055/s-0035-1561623


Abstract

A facile, simple, and mild ligand-free copper-catalyzed reaction provides substituted phenols in good yields from aryl iodides via an O-arylsulfonate intermediate that is hydrolyzed. This protocol offers a wide substrate scope and functional group tolerance.

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Key Words

phenols, copper, ligand-free, water, p-toluenesulfonic acid


ID: J60-Y2016