Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s
Andreas Hafner, Mark Meisenbach and Joerg Sedelmeier*
*Novartis Campus, Novartis Pharma AG, 4002 Basel, Switzerland, Email:
joerg.sedelmeier
novartis.com
A. Hafner, M. Meisenbach, J. Sedelmeier, Org. Lett., 2016, 18, 3630-3633.
DOI: 10.1021/acs.orglett.6b01681
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Abstract
A simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale enables the synthesis of various compounds following a reaction sequence of Hal/Li exchange and electrophilic quench. It was possible to synthesize building blocks within a 1 s total reaction time and with a remarkable throughput of 60 g / h.
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Key Words
arylboronic acids, flow chemistry
ID: J54-Y2016
