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Visible-Light Photoredox Catalyzed Three-Component Cyclization of 2H-Azirines, Alkynyl Bromides, and Molecular Oxygen to Oxazole Skeleton

Lili Chen, Hongji Li*, Pinhua Li and Lei Wang*

*Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China, Email: hongjili1982163.com, leiwang88hotmail.com

L . Chen, H. Li, P. Li, L. Wang, Org. Lett., 2016, 18, 3646-3649.

DOI: 10.1021/acs.orglett.6b01696 (free Supporting Information)


Abstract

A three-component cyclization of 2H-azirines, alkynyl bromides, and molecular oxygen under visible-light photoredox catalysis at room temperature provides a wide range of substituted oxazoles in good yields.

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Key Words

oxazoles, multicomponent reactions, oxygen


ID: J54-Y2016