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General and Mild Cobalt-Catalyzed C-Alkylation of Unactivated Amides and Esters with Alcohols

Nicklas Deibl and Rhett Kempe*

*Inorganic Chemistry II, Catalyst Design, Universitšt Bayreuth, 95440 Bayreuth, Germany, Email: kempeuni-bayreuth.de

N. Deibl, R. Kempe, J. Am. Chem. Soc., 2016, 138, 10786-10789.

DOI: 10.1021/jacs.6b06448 (free Supporting Information)


Abstract

In a borrowing hydrogen methodology, cobalt complexes stabilized with pincer ligands catalyze especially challenging alkylations of unactivated esters and amides with alcohols as alkylating reagents.

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Key Words

alkylation


ID: J48-Y2016