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Copper Iodide Mediated Cyanation of Arylboronic Acids and Aryl Iodides with Ethyl (Ethoxymethylene)cyanoacetate as Cyanating Agent

Chaorong Qi*, Xiaohan Hu, Haitao He

*School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, P. R. of China, Email: crqiscut.edu.cn

C. Qi, X. Hu, H. He, Synlett, 2016, 27, 1979-1982.

DOI: 10.1055/s-0035-1562112 (free Supporting Information)


Abstract

A copper iodide mediated cyanation of arylboronic acids and aryl iodides with ethyl (ethoxymethylene)cyanoacetate as cyanating agent involves a C(sp2)-CN bond cleavage and tolerates a wide range of functional groups to provide the corresponding aryl nitriles in good yields.

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Key Words

copper, nitriles, transition metals, cleavage, arenes, TBHP


ID: J60-Y2016