A General Catalytic Asymmetric Prins Cyclization
Luping Liu, Philip S. J. Kaib, Aurélien Tap and Benjamin List*
*Max-Planck-Institut für Kohlenforschung, Kaiser
Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Email: list
kofo.mpg.de
L. Liu, P. S. J. Kaib, A. Tap, B. List, J. Am. Chem. Soc., 2016, 138, 10822-10825.
DOI: 10.1021/jacs.6b07240
Abstract
Highly acidic confined imino-imidodiphosphate (iIDP) Brønsted acids catalyze the asymmetric Prins cyclization of both aliphatic and aromatic aldehydes. Diverse functionalized 4-methylenetetrahydropyrans are obtained in very good yields and with high regio- and enantioselectivities.
see article for more examples
The Catalytic Asymmetric Intermolecular Prins Reaction
C. D. Díaz-Oviedo, R. Maji, B. List, J. Am. Chem. Soc., 2021, 143, 20598-20604.
Key Words
Prins Reaction, Tetrahydropyrans, Organocatalysis
ID: J48-Y2016
