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Zn(OTf)2-Mediated Expeditious and Solvent-Free Synthesis of Propargylamines via C-H Activation of Phenylacetylene

Prashant B. Sarode, Sandeep P. Bahekar, Hemant S. Chandak*

*Department of Chemistry, G. S. Science, Arts and Commerce College, Khamgaon 444303, India, Email: chemantsgmail.com

P. B. Sarode, S. P. Bahekar, H. S. Chandak, Synlett, 2016, 27, 2209-2212.

DOI: 10.1055/s-0035-1562114 (free Supporting Information)


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Abstract

A Zn(OTf)2-mediated solvent-free synthesis of propargylamines proceeds effectively via A3 coupling of aldehydes, amines, and phenylacetylene. The protocol tolerates a broad range of substituted benzaldehydes, enolizable aldehydes, and formaldehyde. Recyclability of the catalyst, low catalyst loading, and use of inexpensive catalyst are the key features.

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Key Words

Zn(OTf)2, solvent-free synthesis, multicomponent reactions, propargylamines, green chemistry, C-H activation, A3 coupling, propargylamine


ID: J60-Y2016