Building Congested Ketone: Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis
Wenxin Chen, Zheng Liu, Jiaqi Tian, Jin Li, Jing Ma*, Xu Cheng* and Guigen Li
*Institute of Chemistry and Biomedical Sciences, School of
Chemistry and Chemical Engineering, Nanjing University, Nanjing, China, Email:
majing
nju.edu.cn, chengxunju.edu.cn
W. Chen, Z. Liu, J. Tian, J. Li, J. Ma, X. Cheng, G. Li, J. Am. Chem. Soc., 2016, 138, 12312-12315.
DOI: 10.1021/jacs.6b06379
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Abstract
The use of 4-benzyl Hantzsch esters enables the construction of molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly.
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Key Words
benzylation, carbonyl compounds
ID: J48-Y2016
