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Iron-Catalyzed α-Arylation of Deoxybenzoins with Arenes through an Oxidative Dehydrogenative Approach

Tao Chen, Yi-Fan Li, Yang An and Fu-Min Zhang*

*State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China, Email: zhangfmlzu.edu.cn

T. Chen, Y.-F. Li, Y. An, F.-M. Zhang, Org. Lett., 2016, 18, 4754-4757.

DOI: 10.1021/acs.orglett.6b02516 (free Supporting Information)


An iron-catalyzed oxidative dehydrogenation enables an α-arylation of deoxybenzoins with non-prefunctionalized arenes with broad substrate scope and functional group tolerance. The reaction provides efficient access to synthetically useful 1,2,2-triarylethanones.

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Key Words

α-arylation, DDQ


ID: J54-Y2016