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Copper Catalysis for Selective Heterocoupling of Terminal Alkynes

Lebin Su, Jianyu Dong, Long Liu, Mengli Sun, Renhua Qiu, Yongbo Zhou* and Shuang-Feng Yin*

*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Email: zhouybhnu.edu.cn, sf_yinhnu.edu.cn

L. Su, J. Dong, L. Liu, M. Sun, R. Qiu, Y. Zhou, S.-F. Yin, J. Am. Chem. Soc., 2016, 138, 12348-12351.

DOI: 10.1021/jacs.6b07984 (free Supporting Information)


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Abstract

A Cu-catalyzed aerobic Glaser-Hay reaction enables a selective  heterocoupling of terminal alkynes to provide a broad range of unsymmetrical 1,3-diynes in good to excellent yields.

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Key Words

Glaser Coupling


ID: J48-Y2016